Department of Chemistry IITM

Biography

Muraleedharan K. M. hails from the Kannur Dt. of Kerala State. He did his Master’s degree in Chemistry studying at the School of Chemical Sciences, Mahatma Gandhi University during 1991 – 93. Subsequently he joined the research group of Professor Subramania Ranganathan at NIIST trivandrum for doctoral research which focused on the synthesis of models systems to understand molecular – assembly and dis – assembly, the key processes in every biological function. Following a brief stint at IICT Hyderabad (1999 – 2000), he moved to the research group of Professor Mitchell A. Avery at the Univesity of Mississippi, the USA for post – doctoral research where he was working on the development of broad – spectrum anti – infective agents. He joined the department of Chemistry at IIT Madras in 2006 as an Assistant Professor and since then, his group has been working on various projects under the broad umbrella of medicinal – and Bioorganic Chemistry.

Education

2001 – 2006, Post - doctoral Research Associate, Department of Medicinal Chemistry, University. of Mississippi, USA (in the research group of Prof. Mitchell A. Avery).
1999 - Ph. D from NIIST Trivandrum (Supervisor, Prof. Subramania Ranganathan)
1993 - M. Sc from School of Chemical Sciences, Mahatma Gandhi University, Kerala.
1991 - B. Sc from Nirmalagiri College, Calicut University, Kerala.

Research Interests

Development of short synthetic routes to bio - active compounds, and Lead optimizations to target diseases like cancer, Mycobacterium tuberculosis etc.
Studies to understand the mechanisms of drug action, uptake and localization, and also development of diagnostic sensors for biomedical applications.
Design, synthesis and development of new glycolipid mimics for drug delivery applications.
Design of new peptidic/nonpeptidic oligomers with specific conformational preferences in solution and their development into signal transduction modulators and antimicrobial agents.
Design of Supramolecular functional systems.

Representative Publications

Hybridization of the Pharmacophoric Features of Discoipyrrole C and Combretastatin A-4 toward New Anticancer Leads, Jais Kurian, Anvesh Ashtam, Akila Kesavan, Saheer V. Chaluvalappil, Dulal Panda and Muraleedharan K. Manheri, ChemMedChem, 2023; e202300081; doi: 10.1002/cmdc.202300081.

Cancer cell uptake and distribution of oxanorbornane-based synthetic lipids and their prospects as novel drug delivery systems, Akila Kesavan, U. Chandrasekhar Reddy, Jais Kurian and Muraleedharan Kannoth M. Journal of Drug Delivery Science and Technology, 2022, 73, 103439.

Delocalization Effects and Tunable Emission in a Class of Charged Cyclazines with Nitrogen on the Periphery, Jais Kurian, Kanneth S. Shurooque, Venkatachalam Ramkumar, Lakshmi Chakkumkumarath, and Muraleedharan Kannoth M., Org. Lett. 2021, 23, 9, 3354–3358.

Functionalizable Oxanorbornane-based Head Group in the Design of New Non-ionic Amphiphiles and Their Drug Delivery Properties, S. Soumya, D. Sirisha Janni,U. Chandrasekhar Reddy, K. M. Muraleedharan, Materials Science & Engineering C, 2020, 112, 110857.

Electronically-tuned triarylmethine scaffolds for fast and continuous monitoring of H2S levels in biological samples, Kalluruttimmal, Ramshad; Thekke Thattariyil, Divya; Panthalattu Parambil, Archana; Sen, Ashis Kumar; Chakkumkumarath, Lakshmi; Manheri, Muraleedharan Kannoth, Analyst, 2019, 144(14), 4210-4218

Gel-based Supramolecular ON-OFF Switch from Aryl-triazolyl Peptides . with Excellent Chiro-optical-, Thixotropic-, and Self-healing Characteristics, Bhartendu K. Srivastava and Kannoth M. Muraleedharan, Soft Matter, 2018, 14, 1631-1636.

Towards a fragment-based approach in gelator design: halogen effects leading to thixotropic, mouldable and self-healing systems in aryl-triazolyl amino acid-based gelators, Bhartendu K. Srivastava and Kannoth M. Muraleedharan, Chem. Commun. 2017, 53, 4485-4488.

Sulfamide Lattice Restructuring to Dimensionally Controlled Molecular Arrays and Gel-forming Systems, S. V. Raghava, P. Gopinath, Bhartendu K. Srivastava, V. Ramkumar, and K. M. Muraleedharan, Chem. Eur. J., 2017, 23, 3658-3665.

FtsZ inhibition and Redox modulation with one chemical scaffold: Potential use of Dihydroquinolines against Mycobacteria, Sridevi Duggirala, John Victor Napoleon, Rakesh P. N,Senu Adeeba V., Muraleedharan K. M., Mukesh Doble , Eur. J. Med. Chem. 2016, 123, 557-567.

N-Methylpyrrolidone Hydroperoxide/Cs2CO3 as an Excellent Reagent System for the Hydroxy-Directed Diastereoselective Epoxidation of Electron-Deficient Olefins Napoleon John Victor, Gana Janardhanan and Kannoth Manheri Muraleedharan, Chem. Eur. J., 2015, 42, 14742-14747.

Can Helical Peptides Unwind One Turn at a Time? – Controlled Conformational Transitions in α,β2,3-Hybrid Peptides, Dhayalan Balamurugan and Kannoth M. Muraleedharan, Chem. Eur. J, 2015, 21(26), 9332-9338.

Peptide turns through just ‘one atom’! A sulfamide group nucleates folding and stabilizes new supramolecular topologies in short peptide, Pushparathinam Gopinath, Venkatachalam Ramkumar and Kannoth Manheri Muraleedharan, CrystEngComm, 2014, 16, 10371-10375.

N-Substituted 1,2-Dihydroquinolines as Anticancer Agents: Electronic Control of Redox Stability, Assessment of Antiproliferative Effects, and Mechanistic Insights, Napoleon John Victor, Ramasamy Sakthivel, Kannoth Manheri Muraleedharan and Devarajan Karunagaran, ChemMedChem, 2013, 8, 1623-1628.

Unprecedented Torsional Preferences in trans-β2,3-Amino acid Residues and Formation of 11-Helices in α,β2,3-Hybrid Peptides, Dhayalan Balamurugan and Kannoth M. Muraleedharan, Chem. Eur. J., 2012, 18, 9516-9520.

Highly Chemoselective Esterification Reactions and Boc/THP/TBDMS Discriminating Deprotections under Samarium(III) Catalysis, Gopinath Pushparathinam, Nilaya Surapaneni and Muraleedharan Kannoth Manheri, Org. Lett., 2011, 13, 1932-1935.

Multi-chelation approach towards natural product-like skeletons: one-pot access to a nitrogen-containing tetracyclic framework from AlaAla dipeptide, Kasipandi Vellaisamy, John Victor Napoleon, Ramkumar Venkatachalam and Muraleedharan Kannoth Manheri, Chem. Commun., 2010, 46, 9212-9214.

As many as six tandem reactions in one step! – Unprecedented formation of highly functionalized benzothiophenes, Gopinath Pushparathinam, Nilaya Surapaneni, Debiranjan Tripathy, Ramkumar Venkatachalam, and Muraleedharan Kannoth Manheri, Chem. Commun., 2009, 46, 7131-7133.