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DR. MURALEEDHARAN, K. M.

Professor

Muraleedharan K. M. hails from the Kannur Dt. of Kerala State. He did his Master’s degree in Chemistry studying at the School of Chemical Sciences, Mahatma Gandhi University during 1991 – 93. Subsequently he joined the research group of Professor Subramania Ranganathan at NIIST trivandrum for doctoral research which focused on the synthesis of...

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Latest News

No.
01

Development of short synthetic routes to biologically active compounds.

No.
02

Studies to understand the mechanisms of drug action, uptake and localization using molecular probes and development of delivery systems for the specific trafficking of drug molecules to their sites of action.

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03

Design, synthesis and development of new glycolipid mimics for material design and membrane engineering.

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04

Design of new peptidic/nonpeptidic oligomers with specific conformational preferences in solution and their development into signal transduction modulators and antimicrobial agents.

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05

New organic materials through supramolecular foldamer assembly.

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06

Design and synthesis of broad-spectrum anti-infective agents to target tropical diseases

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07

Development of mechanism-based reversible inhibitors of kinases to target cancer

No.
08

Studies to understand the mechanisms of drug action, uptake and localization using molecular probes and development of delivery systems for the specific trafficking of drug molecules to their sites of action

No.
09

Eneavors directed towards the introduction of new functional or recognitionelements to peptide fragments or protein structures to modulate their biological profile.

Medicinal & Bio-Organic Chemistry Group

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Reserach Highlights

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Research

Synthesis of New Cyclazines and 4,5-Diaryl-1H-pyrrol-3(2H)-one unit in Discoipyrroles from Indolizinone-DMAD Cycloadducts

Jais Kurian.  and Muraleedharan K. M.*

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Research

Electronically-tuned Triarylmethine Scaffold for Fast and Continuous Monitoring of H2S Levels in Biological Samples

Ramshad Kalluruttimmal, Divya Thekke Thattariyil, Archana Panthalattu Parambil, Ashis Kumar Sen, Lakshmi Chakkumkumarath * and Kannoth Manheri Muraleedharan *

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Research

1-Hydroxymethyl-7-Oxabicyclo[2.2.1]hept-2-ene Skeleton in Enantiopure form through Enzymatic Kinetic Resolution

U. Chandrasekhar Reddy, and Kannoth Manheri Muraleedharan *

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Research

Serine- and Threonine-derived Diamine Equivalents for Site-specific Incorporation of Platinum Centers in Peptides, and Anticancer Potential of these Conjugates

Sateeshkumar K., Kasipandi V., Soumya Saroj, Nalini V., Karunagaran D  and Muraleedharan. K. Manheri *

 

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Research

Broad spectrum Anti-infective Properties of Benzisothiazolones and the Parallels in their Anti-bacterial and Anti-fungal effects

P. Gopinath,  R. K. Yadav, P. K. Shukla, K. Srivastava, S. K. Puri, and K. M. Muraleedharan *