Hema Chandra Kotamarthi’s research interest lies in understanding the physicochemical properties of Biomolecules, in particular proteins and enzymes. Prior to his appointment as an Assistant professor at the IIT Madras in September 2020, he was a research scientist and Howard Hughes Medical Institute research associate at the Department of Biology, Massachusetts Institute of Technology in the labs of Profs. Tania Baker and Bob Sauer. His interest in studying the kinetic and mechanical properties of proteins and enzymes stemmed during his graduate studies in Dr. Sri Rama Koti Ainavarapu’s lab at TIFR. Apart from research and teaching activities, he is also very interested in science communication and popularization and has written science articles for “Sakshi”, a Telugu daily. In addition, he has been a lead organizer of “Young Investigator Meeting- Boston”- 2018 & 2015, a platform that brings together academicians from India and researchers of Indian origin in the USA.
Hema Chandra Kotamarthi, Robert Sauer, Tania Baker. “The non-dominant AAA+ ring in the ClpAP protease functions as an anti-stalling motor to accelerate protein unfolding and translocation”, Cell Reports, 2020, Vol 30, 2644-2654.
Amaris Torres-Delgado, Hema Chandra Kotamarthi, Robert Sauer, Tania Baker. “The intrinsicallydisordered N-terminal extension of the ClpS adaptor reprograms its partner AAA+ ClpAP protease”, Journal of Molecular Biology, 2020, Vol 432, 4908-4921.
Adrian Olivares*, Hema Chandra Kotamarthi*, Benjamin Stein, Robert Sauer, Tania Baker, “Effect of directional pulling on mechanical protein degradation by ATP-dependent proteolytic machines”, Proceedings of National Academy of Sciences, USA, 2017, Vol 114, E6306-E6313. (*Equal Contribution)
Hema Chandra Kotamarthi,Anju Yadav, and Sri Rama KotiAinavarapu. “Small peptide binding stiffens the ubiquitin-like protein SUMO1”, Biophysical Journal, 2015, Vol 108, 360-367.
Hema Chandra Kotamarthi, Satya Narayan, Sri Rama KotiAinavarapu. “Mechanical unfolding of ribose binding protein (RBP) and its comparison with other periplasmic binding proteins (PBPs)”, Journal of Physical Chemistry B, 2014, Vol 39, 11449-11454.
Venkatraman Ramanujam, Hema Chandra Kotamarthi, Sri Rama KotiAinavarapu. “Ca2+ bindingenhanced mechanical stability of an archaeal crystallin”, PLOS ONE, 2014, Vol 9, e94513.
Hema Chandra Kotamarthi,Riddhi Sharma, Satya Narayan, Sayoni Ray, and Sri Rama KotiAinavarapu. “Multiple unfolding pathways of leucine binding protein (LBP) probed by single- moleculeforce spectroscopy (SMFS)”, Journal of the American Chemical Society, 2013, Vol 135, 14768-14774.
Hema Chandra Kotamarthi, Riddhi Sharma, Sri Rama KotiAinavarapu. “Single- Molecule Studieson PolySUMO Proteins Reveal Their Mechanical Flexibility”, Biophysical Journal, 2013, Vol 104;2273-2281.