DEPARTMENT OF CHEMISTRY
INDIAN INSTITUTE OF TECHNOLOGY MADRAS
DEPARTMENT OF CHEMISTRY
INDIAN INSTITUTE OF TECHNOLOGY MADRAS
DEPARTMENT OF CHEMISTRY
INDIAN INSTITUTE OF TECHNOLOGY MADRAS
Yogesh Shelke earned his M.Sc. in Organic Chemistry from the University of Pune and completed his Ph.D. in Organic Synthesis at IIT Bombay in 2018 under Prof. Santosh J. Gharpure. He then worked with Prof. K. C. Nicolaou at Rice University on the total synthesis of anticancer natural products until September 2020. In October 2020, he joined Prof. Martin Burke’s group at the University of Illinois at Urbana-Champaign, focusing on renal-sparing derivatives of amphotericin B, which led to a new antifungal clinical candidate. In May 2022, he started working at Novo Nordisk Inc. in Boston on the Medicinal Chemistry of oligonucleotides. In May 2025, he became an Assistant Professor in the Department of Chemistry at IIT Madras, where his research interests include total synthesis of natural products, structural reorganization, skeletal editing, site-selective functionalization of natural products, and drug discovery.
Maji, A. ; Soutar, C. P.; Zhang, J. ; Lewandowska, A.; Uno, B. E.; Yan, S.; Shelke, Y.; Murhade, G. Nimerovsky, E.; Borcik, C. G.; Arango, A. S.; Lange, J. D.; Lyu, Y.; Bailey, K. L.; Roady, P. J.; Holler, J. T.; Khandelwal, A.; SantaMaria, A. M.; Sanchez, H.; Juvvadi, P. R.; Johns, G.; Hageman, M. J.; Krise, J.; Gebremariam, T.; Youssef, E. G.; Bartizal, K.;Marr, K. A.; Steinbach, W. J.; Ibrahim, A. S.;Patterson, T. F.; Wiederhold, N. P.; Andes, D. R.; Pogorelov, T. V.; Schwieters, C. D.;Fan, T. M.; Chad M. Rienstra, C. M.*; Burke, M. D.* “Tuning Sterol Extraction Kinetics Yields a Renal Sparing Antifungal” Nature, 2023, 623, 1079–1085.
Nicolaou, K. C.*; Pan, S.; Shelke, Y.; Rigol, S.; Ye, Q.; Das, D. “A Unified Strategy for the Total Syntheses of Eribulin and a Macrolactam Analogue of Halichondrin B” Proc. Natl. Acad. Sci. U.S.A., 2022, 119, e2208938119.
Nicolaou, K. C.*; Pan, S.; Shelke, Y.# ; Ye, Q. # ; Das, D.; Rigol, S. “A Highly Convergent Total Synthesis of Norhalichondrin B” J. Am. Chem. Soc. 2021, 143, 20970–20979 ( # Contributed equally).
Nicolaou, K. C.*; Pan, S.; Shelke, Y.# ; Das, D. # ; Ye, Q. # ; Lu, Y.; Sau, S.; Bao, R.; Rigol, S. “A Reverse Approach to the Total Synthesis of Halichondrin B” J. Am. Chem. Soc. 2021, 143, 9267–9276 ( # Contributed equally).
Nicolaou, K. C.*; Shelke, Y. G. # ; Dherange, B. D. # ; Aaron, K; Baiwei, L.; Christine, G.; Joseph, S.; Mikhail, H.; Monette, A.; Julia, G. “Design, Synthesis and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam and Carbocyclic Macrocycles, Epoxide, Aziridine and 1,1- Difluorocyclopropane and Other Fluorine Residues” J. Org. Chem. 2020, 85, 2865–2917. ( # Contributed equally).
Gharpure, S. J.*, Shelke, Y. G. “Lewis Acid Mediated Cascade Friedel−Crafts/Alkyne Indol-2-yl Cation Cyclization/Vinyl Cation Trapping for the Synthesis of N‑Fused Indole Derivatives” Org. Lett. 2017, 19, 5406−5409.
Gharpure, S. J.*; Shelke, Y. G. “Cascade Radical Cyclization of N‑Propargylindoles: Substituents Dictate Stereoselective Formation of N‑Fused Indolines versus Indoles” Org. Lett. 2017, 19, 5022−5025.
Gharpure, S. J.*; Shelke, Y. G.; Kumar, D. P. “Counter-Ion-Dependent Alkyne Iminium Ion Cyclization for Divergent Synthesis of N-Fused Indolylidine, Indole, and Indoline Derivatives Promoted by the Lewis/Brønsted Acid” Org. Lett. 2015, 17, 1926−1929. 17.
