Department of Chemistry IITM

Biography

Satyajit Roy began his scientific training in West Bengal, where he earned his master’s degree in chemistry from the University of Kalyani. Driven by a strong interest in transition-metal chemistry, he pursued doctoral research on transition metal–catalyzed carbene and nitrene chemistry under the supervision of Prof. Buddhadeb Chattopadhyay at the Centre of Biomedical Research, Lucknow, and was awarded his Ph.D. degree by Banaras Hindu University.

Following his Ph.D., he moved to the United States for postdoctoral research with
Prof. Rudi Fasan at the University of Rochester, New York, where he developed expertise in biocatalysis within a highly collaborative research environment. In 2023, he continued his postdoctoral work in the same group at the University of Texas at Dallas. In 2026, he joined the Indian Institute of Technology Madras (IIT Madras) as an Assistant Professor. His current research focuses on advancing chemical reactivity and catalysis, with an emphasis on sustainable and transformative strategies in modern chemistry.

Education

2023 - 2025: Post doctoral fellow, Department of Chemistry & Biochemistry, The University of Texas at Dallas, Texas, USA
2021 - 2023: Post doctoral fellow, Department of Chemistry, The University of Rochester, NY, USA
2015 - 2020: Ph. D Department of Chemistry and Biochemistry, Banaras Hindu University, Varanasi, India.
2013 - 2015: Master of Science, University of Kalyani, Kalyani, India
2010 - 2013: Bachelor of Science (Chemistry Honors), University of Kalyani, Kalyani, India

Research Interests

Enzyme catalysed “new to nature” reaction.
Protein engineering for enhancement of reactivity and selectivity.
Chiral ligand development using the toolbox of bio-catalysis.
Asymmetric Synthesis of organic compounds using photobiocatalysis

Representative Publications

Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridotriazoles. Roy, S.; Wang, Y.; Zhao, X.; Dayananda, T.; Chu, J.-M.; Zhang, Y.; Fasan, R. J. Am. Chem. Soc. 2024, 146, 19673–19679.
https://doi.org/10.1021/jacs.4c06103

Stereoselective construction of β-, γ- and δ-lactam rings via enzymatic C–H amidation. Roy, S., Vargas, D.A., Ma, P. et al. Nat Catal. 7, 65–76 (2024).
https://doi.org/10.1038/s41929-023-01068-2.

Biocatalytic Strategy for Construction of sp3-Rich Polycyclic Compounds from Directed Evolution and Computational Modeling. Vargas, D.A., Ren, X., Sengupta, A. et al. Nat. Chem. 16, 817–826 (2024).
https://doi.org/10.1038/s41557-023-01435-3.

Road Map for the Construction of High-Valued N-Heterocycles via Denitrogenative Annulation. Roy, S.; Das, S. K.; Khatua, H.; Das, S.; Chattopadhyay, B. Acc. Chem. Res. 2021, 54, 4395–4409.
https://pubs.acs.org/doi/10.1021/acs.accounts.1c00563

Iron‐Catalyzed Radical Activation Mechanism for Denitrogenative Rearrangement Over C(sp 3 )–H Amination. Roy, S.; Das, S. K.; Khatua, H.; Das, S.; Singh, K. N.; Chattopadhyay, B. Angew. Chem. Int. Ed. 2021, 60,
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202014950

Iron-Catalyzed Amination of Strong Aliphatic C(sp 3 )–H Bonds. Das, S. K.; Roy, S.; Khatua, H.; Chattopadhyay, B. J. Am. Chem. Soc. 2020, 142, 16211 16217. https://pubs.acs.org/doi/full/10.1021/jacs.0c07810

Iron(II)‐Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation. Roy, S.; Khatua, H.; Das, S. K.; Chattopadhyay, B. Angew. Chem. Int. Ed. 2019, 58, 11439-11443.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201904702

Ir-Catalyzed Intramolecular Transannulation/C(sp 2 )–H Amination of 1,2,3,4-
Tetrazoles by Electrocyclization. Das, S. K.; Roy, S.; Khatua, H.; Chattopadhyay, B. J. Am. Chem. Soc. 2018, 140, 8429-8433.
https://pubs.acs.org/doi/full/10.1021/jacs.8b05343

Cobalt(II)-Based Metalloradical Activation of 2-(Diazomethyl)pyridines for Radical Transannulation and Cyclopropanation. Roy, S.; Das, S. K.; Chattopadhyay, B. Angew. Chem. Int. Ed. 2018, 57, 2238-2243.
https://doi.org/10.1002/anie.201711209