Definition and classification of sugars, nomenclature, aldoses and ketoses, configuation of (+)- glucose: the Fischer proof, ring structures and conformation, mutarotation, anomericity, naturally occurring monosaccharides, oligosaccharides and polysaccharides, three-dimensional structure of macromolecular carbohydrates.
Methods for isolation, purification and structural analysis, complete and partial hydrolysis, methylation analysis, Smith degradation, chromatographic and electrophoretic techniques, advanced spectroscopic techniques including fast atom bombardment mass spectrometry and two-dimensional NMR.
Chemical ractions of carbohydrates, oxidation, reduction, formation of derivatives, glycosides, ethers, esters and cyclic acetals, modern chemical transformations, methods for the formation and cleavage of O-glycosidic bond, use of protecting groups, chemical and enzymatic synthesis of oligosaccharides, carbohydrates as chiral synthons for natural products synthesis.
Carbohydrate biopolymers, animal glycoproteins, blood-group substances, plant and algal glycoproteins, proteoglycans and glycosaminoglycans, glycolipids, structural basis for the biological functions of glycan chains in glycoconjugates, carbohydrates and biological molcular recognition, carbohydrate componets of nucleic acids and antibiotics.
References:
J.F. Kennedy and C.A. White, Bioactive Carbohydrates, Ellis Horwood, New York, 1983
R.W. Binkley, Moden Carbohydrate Chemistry, Marcell and Dekker, New York., 1988
J.F. Kennedy (Ed.) Carbohydrate Chemistry, Oxford University Press, Oxford, 1988.
