Course Objectives: Learn various asymmetric transformations and employ such reactions in asymmetric organic synthesis of important chiral molecules.
Learning Outcome: At the end of the course, the learners should be able to:
Apply asymmetric transformations in a logical manner for the synthesis of chiral molecules.
Stereoselective reactions: Classification, importance and advantages; diastereoselective reactions.
Asymmetric synthesis: Importance, classification and principle; modes of asymmetric induction
Metal catalyzed asymmetric enantioselective oxidation, reduction, C-C bond forming reactions, allylic substitution, cyclization, and other important reactions.
Chiral organocatalysts including phase transfer catalysts and hydrogen-bonding catalysts, and supported chiral catalysts.
Kinetic resolution, parallel kinetic resolution, dynamic kinetic resolution and dynamic thermodynamic resolution.
Chiral poisoning, chiral activation, desymmetrization, nonlinear effect, autocatalysis, auto induction, double diastereoselection and remote chiral induction in asymmetric synthesis
Determination of optical purity using NMR, GC and HPLC techniques including principles, determination of absolute configuration by NMR and X-Ray crystallography.
Application of asymmetric synthesis in the industrially relevant molecules such as L-DOPA, (S)-metolachlor, carbapenem and menthol.