CY 6126 : Green Organic Synthesis: Principles and Applications

Course Objectives: Learn the importance of minimizing waste, saving power and doing organic synthesis according to the principles of green chemistry

Learning outcomes: At the end of the course, the learners should be able to:

Create awareness for reducing waste, minimizing energy consumption in organic synthesis.

Implement techniques of green synthesis in organic reactions

Course Contents:

Green Chemistry Definition, need for Green chemistry, evolution of Green Chemistry, principles of Green Chemistry.

Classification of organic reactions under Green chemistry principles: a) Atom economic and non-toxic byproduct reactions: rearrangements, addition reaction, condensations, cascade strategies under catalysis, b) atom uneconomic reactions: substitutions, eliminations, Wittig reactions, degradation reactions

Green Strategies and techniques for Organic Synthesis: use of Microwave, Sonochemsitry, Ball mill technique, electrochemical reactions, photochemical reactions,

Catalysis: Principles of various catalysis techniques in terms of Green Organic Synthesis

i) Homogeneous, ii) Heterogeneous, iii) bio (enzyme) catalysis, iv) catalysis with non-toxic metals (Ca, Fe, Co, etc.), v) solid supported catalysis, vi) metal free/organocatalysis, vii) Visible light catalysis viii) phase transfer catalysis Alternative/Green Solvents for Organic Synthesis i) Water, ii) Ionic liquids, iii) Supercritical liquids (SCL), iv) Poly(ethylene glycol) (PEG), v) Fluorous biphasic Solvents

Comparison of greenness of solvents

Understanding the role/effect of these solvents on organic reactions

Solvent Free Organic Synthesis

Reactions at Room Temperature

Applications of the Green strategies in Organic Synthesis

Comparing various organic reactions under classical conditions and Green conditions.

Text Books:

1. Green Chemistry: An introductory text by Mike Lancaster, RSC publishing, 2nd Edition, 2010.
2. Green Chemistry: Theory and Practice by Paul T. Anastas and John C. Warner, Oxford University Press, Oxford, 1998.
3. Green Chemistry: Environment Friendly Alternatives by Rashmi Sanghi and M M Srivastava, Narosa Publishing House, Delhi, 2003.
4. Strategies for Green Organic Synthesis, by V. K. Ahulwalia, Ane Books Pvt. Ltd. 1st Edition, 2012.