• Recent Publications
  • Patents
  • Selected Publications
  1. Lee, D. H., Murthy, N. N., Karlin, K. D. (2007) Copper–Dioxygen Reactivity Using Dinucleating Ligands. Bull. Chem. Soc. Jpn.; 80, 732–742.

  2. Li, L; Murthy, N. N.; Telser, J.; Zakharov, L. N.; Yap, G. P. A.; Rheingold, A. L.; Karlin, K. D.; Rokita, S. E. (2006). Targeted Guanine Oxidation by a Dinuclear Copper(II) Complex at Single Stranded /Double-Stranded DNA Junctions. Inorg. Chem.; 45; 7144-7159.

  3. Sunita, T..; Murthy, N. N.; Narducci Sarjeant, A. A.; Karlin, K. D.; Rokita, S. E. (2006) Selective DNA Strand Scission with Binuclear Copper Complexes: Implications for an Active Cu2-O2Species. J. Am. Chem. Soc.; 128; 7003-7008

  4. Sabaih, S.; Varghese, B. Murthy, N.N. Novel cobalt(II) complexes containing a new bidentate ligand: Synthesis and spectroscopic characterizations. J. Chem. Cryst. 36, 147-151, 2006

  5. Sutha, G. S., Varghese, B. and Murthy, N. N. The perchlorate salt of the novel diprotonated dinucleating ligand 1,3-bis{[2-(2-pyridinio)ethyl][2-(2-pyridyl)ethyl]amino}benzene, Acta Cryst. 2005, C61, o380-o382.

  6. Urmila, P. C.,Varghese, B and Murthy, N. N. Bis[µ-2-{bis(2-pyridylethyl)amino}phenolato] bis[aquanickel(II)]dinitrate tetrahydrate.Acta Cryst. E59, 627-629, 2003.

  7. Murthy, N.N., Mohammad Mahroof-Tahir, and Kenneth D. Karlin; Dicopper(I) Complexes of Unsymmetrical Binucleating Ligands and Their Dioxygen Reactivities, Inorganic Chemistry2001; 40(4); 628-635.

    1. Rhames F. C., Murthy N. N., Karlin K.D. and Blackburn N. J. J Biol. Inorg. Chem. 2001, 6, 567.
  8. Markus Schatz, Michael Becker, Florian Thaler, Frank Hampel, Siegfried Schindler, Richard R. Jacobson, Zoltán Tyeklár, Murthy,N. N. Phalguni Ghosh, Qin Chen, Jon Zubieta, and Kenneth D. Karlin ; Copper(I) Complexes, Copper(I)/O2 Reactivity, and Copper(II) Complex Adducts, with a Series of Tetradentate Tripyridylalkylamine Tripodal Ligands, Inorganic Chemistry2001; 40(10); 2312-2322.

  9. Corsi, D.M.; Murthy, N. N. ; Young, V.G.; Karlin,K.D. “Synthesis, Structure, and Solution NMR Studies of Cyanide-Copper(II) and Cyanide-Bridged Iron(III)-Copper(II) Complexes” Inorg. Chem. 1999, 38, 848.

  10. Obias, H. V.; Lin, Y.; Murthy, N. N.; Pidcock, E.; Solomon, E.I.; Ralla, M.; Blackburn, N.J.; Neuhold, Y-M.; Zuberbuhler, A.D.; Karlin,K.D. “Peroxo-, Oxo-, and Hydroxo-Bridged Dicopper Complexes: Observation of Hexogenous Hydrocarbon Substrate Hydroxylation” J. Am. Chem. Soc1998, 120, 12960-12961.

  11. Murthy, N. N. ; Karlin,K.D.; Luchinat, C. and Bertini, I. “1H NMR and Electronic Relaxations in Paramagnetic Dinuclear Copper(II) Compounds”J. Am. Chem. Soc1997, 119, 2156-2162.

  12. Nanthakumar, A.; Fox, S.; Murthy, N.N.; Karlin, K.D., ” Inferences from the 1H-NMR Spectroscopic Study of an Antiferromagnetically Coupled Heterodinuclear Fe(III)-(X)-Cu(II) S = 2 Spin System (X = O2-, OH-) “, J. American Chemical Soc1997, 119, 3898-3906.

  13. Frey, S.F.; Murthy, N.N. ; Weintraub, S. T.; Thompson S. T. and K.D. Karlin. “Hydrolysis of Unactivated Esters and Acetonitrile Hydration by a Hydroxo-Diopper Complex “ Inorg. Chem. 1997, 36, 956.

  14. Lee, D.-H.; Murthy, N. N.; Karlin, K. D. “Binuclear Copper Complexes based on the 6,6′-bis[bis(2-pyridylmethyl amino]-2,2′-bipyridyl ligand” Inorg. Chem. 1997, 36, 5785.

  15. Lee, D.-H.; Murthy, N. N.; Lin, Y.; nasir, S.; Karlin, K. D. “Copper-Ion Complexes with Derivatized Chelating Pterin Ligands” Inorg. Chem. 1997, 36, 6328.

  16. Cox, C.; Ferraris, D., Murthy, N. N. and Lectka, T. “Copper(II)-Catalyzed Amide Isomerization: Evidence for N-Coordination”. J. American Chemical Soc. 1996, 118, 5332-5333.

  17. Reedy, B.J.; Murthy, N. N.; Karlin, K. D. and Balckburn, N.J. “Isocyanides as Ligand-Directed Indicators of Cu(I) Coordination in Copper Proteins. Probing the Inequivalence of the Cu(I) Centers in Reduced Dopamine-b-monooxygenase” J. American Chemical Soc1995, 117, 9826.

  18. Dong-Heon Lee; Wei, N.; Murthy, N. N.; Tyeklar, Z; Karlin, K. D.;Kaderli, S.;Jung, B. and Zuberbuhler, A.D. “Revrsible O2-Binding to a Dinuclear Copper(I) Complex with Linked TMPA {tris(2-pyridylmethyl)amine} Units: Kinetic-Thermodynamic Comparisions to Mononuclear Analogues” J. American Chemical Soc. 12498-12513, 117, 1995.

  19. Murthy, N. N. and Karlin, K.D.”Biomimetic Copper-Dioxygen Chemistry: Reversible O2-Binding and Mechanistic Insights into Cu(I)/O2 Mediated Arene Hydroxylation and Amide Hydrolysis”, Mechanistic Bioinorganic Chemistry, Advances in Chemistry Series, American Chemical Society; Eds. Thorp, H.H. and Pecoraro, V. L., 1995, Ch. 6, p165-192.

  20. Frey, S.F.; Sun, H.H.J.; Murthy, N.N. and K.D. Karlin. “A New Trinuclear Copper Complex And Its Reaction With Plasmid DNA” Inorg. Chem. Acta1996, 242, 329.

  21. Lee, D.-H.; Murthy, N.N. and Karlin, K.D. “Copper(I)/Dioxygen Reactivity with Dinuclear Compounds: Catalytic Oxygenation and Oxo-transfer to a Ketone” Inorg. Chem. 1996, 35, 804.

  22. Martens, C.F; Murthy, N. N., Obias, H.V. and Karlin, K.D. “Heme/non-heme iron-oxo complexes”, J. Chemical Soc. Chemical Commu. 1996, 629.

  23. Karlin, K.D.; Fox, S.; Nanthakumar, A.; Murthy, N. N., Wei, N.; Obias, H.V.; Martens, C.F. “Copper-Dioxygen Chemistry and Modeling the Fe-Cu center in Cytochrome c Oxidase”, Pure and Applied Chemistry 1995, Vol 67, No. 2, 289-296.

  24. Karlin, K.D., Nanthakumar, A.; Fox, S.; Murthy, N.N.; Ravi, N.; Huynh, B.H.; Orosz, R.D.; Day, E.P.; Hegan, K.S.; Balckburn, N.J. “A Structural and Reactivity Model for the Cytochrome C Oxidase Fe-Cu Dinuclear Active Site: X-ray Structure and Physical Properties of the Oxo-bridged Complex [(F8-TPP)Fe-O-Cu(TMPA)]+, F8-TPP = tetrakis(2,6-diflurophenyl)porphyrin, TMPA = tris(2-pyridylmethyl)amine”, J. American Chemical Soc1994, 116, 4753-4763.

  25. Wei, N; Dong-Heon Lee, Murthy, N. N.; Tyeklar, Z; Karlin, K. D.;Kaderli, S.;Jung, B. and Zuberbuhler, A.D.,”Kinetic preference without thermodynamic stabilization in the Intra- vs Inter-molecular formation of copper-dioxygen complexes “ Inorg. Chem. 1994, 33, 4625-4626.

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  26. Wei, N.; Murthy, N. N.; Chen,Q.; Zubieta, J. and Karlin, K. D.”Copper(I)/Dioxygen Reactivity of Mononuclear Complexes with Pyridyl and Quinolyl Tripodal Tetradentate Ligands: Reversible Formation of Cu/O2 = 1:1 and 2:1 adducts”. Inorg. Chem.1994, 33, 1953-1965

  27. Wei, N.; Murthy, N. N.; Tyeklar, Z. and Karlin, K. D. “Copper(I) Complexes with Pyridyl and Imidazolyl Containing Tripodal Tetradentate Ligands and their Reactions with OInorg. Chem. 1994, 33, 1177.

  28. Wei, N; Murthy, N. N. and Karlin, K. D. “Chemistry of pentacoordiante [LCuIIL]+ complexes with quinolyl containing tripodal tetradentate ligands”, Inorg. Chem. 1994, 33, 6093-6100.

  29. Murthy, N. N.; Mahroof-Tahir, M. and Karlin, K. D. “Facile Amide Hydrolysis Effected by Dinuclear Copper Complexes”, J. American Chemical Soc.1993 , 115, 10404-10405.

  30. Murthy, N. N. and Karlin, K.D. “A Dinuclear Zinc-Hydroxide Complex which Traps Atmospheric Carbon Dioxide: Formation of a Tri-Zinc complex with a Triply-Bridging Carbonate group”, J. Chem. Soc., Chem. Commun. 1993, 1236-1238.

  31. Nanthakumar, A.; Fox, S.; Murthy, N.N.; Karlin, K.D.; Ravi, N.; Huynh, B.H.; Orosz, R.D.; Day, E.P.; Hegan, K.S.; Balckburn, N.J. “Oxo- and Hydroxo-Bridged (Porphyrin)Iron(III)-Copper(II) species as Cytochrome C Oxidase Models: Acid-Base Inter conversions and X-ray Structure of the Fe(III)-O2-Cu(II) complex”, J. American Chemical Soc1993, 115, 8513-8514.

  32. Tyeklar, Z.; Jacobson, R. R.; Wei, N.; Murthy, N. N.; Farooq, A.; Zubieta, Z. and Karlin, K. D. “Reversible Reaction of O2 ( and CO) with a Copper(I) Complex: Structure of the trans-m-1,2-peroxo-dicopper(II) product”, J. American Chemical Soc. 1993, 115, 2677-2689.

  33. Sanyal, I.; Murthy, N.N. and Karlin, K.D. “A Copper(I) Complex and its Oxygenation Chemistry using a Dinucleating Ligand with Pendent Alkene Group”,Inorg. Chem. 1993, 32, 5330-5337.

  34. Fox, S.; Nanthakumar, A.; Wei, N.; Murthy, N. N., and Karlin, K. D. “Investigations of Dioxygen Reactivity with Synthetic Models of the Metalloproteins Hemocyanin and Cytochrome C Oxidase”, Pure and Applied Chemistry1993, 65, 2335-2342.

  35. Posner, G.H.; Dai, H.; Afarinkia, K.; Murthy, N.N.; Guyton, K.Z. and Kensler, T.W. “Asymmetric Total Synthesis, X-ray Crystallography, and Preliminary Biological Evaluation of 1-(1′-Hydroxy-ethyl)-25-hydroxyvitamin D3 Anlogs of Natural Calcitriol”, J. Org. Chem. 1993, 58, 7209-7215.

  36. Abraham, S.P.; Murthy, N. N.; Netaji, M.; Samuelson, A.G. “Reactions of Copper(I) Aryloxides with PhNCS: Steric and Ligand Control in the Oligomerization of [N-phenyl-imino(aryloxy)methanethiolato]copper(I) complexes”, Inorg. Chem1993, 32, 1739-1745.

  37. Mahroof-Tahir, M.; Murthy, N. N.; Karlin, K. D.; Blackburn, N. J.; Shaikh, N. J. and Zubieta, J. “Room Temperature Stable Peroxo- and Hydro-peroxo Copper Complexes”, Inorg. Chem. 1992, 31, 3001.

  38. Murthy, N. N.; Manohar, H.; Samuelson, A. G. and Chandrasekar, J. “Cumulative Anomeric Effect: A Theoretical and X-ray Diffraction Study of Orthocarbonates”, J. Am. Chem. Soc., 1990, 112, 2937.

  39. Murthy, N. N., Novel Reactions of Copper(I) phenoxide with Heteroallenes: A Synthetic and Structural Study. Ph.D. Thesis, Indian Institute of Science, Bangalore, India, 1990.

  40. Murthy, N. N.; Samuelson, A.G.; Manohar, H. “Reaction of Copper(I)phenoxide with PhNCS: Formation and X-ray Structure of a Novel Copper(I) hexameric Complex”, JCS. Chem. Comm1989, 1803.

  41. Murthy, N. N. and Samuelson, A. G. “Synthetic Utility of Copper(I) phenoxide Complexes”, Proc. Indian Acad. Sci. 1989, 55A, 383-391.

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  42. Murthy, N. N. and Samuelson, A. G. “The Effect of Nitrogen Donors on the Reactivity of Copper(I) phenoxides: Synthesis of Thioncarbonates”,Tetrahedron Lett. 1988, 29, 827.

  43. Murthy, N. N. and Samuelson, A. G. “Synthesis of Arylorthocarbonates using Copper(I)phenoxides “, Tetrahedron Lett. 1986, 27, 991.

  44. Murthy, N. N. and Samuelson, A. G. “Thiocarbonyl to Carbonyl group Transformation using Copper(I) “, Tetrahedron Lett. 1986, 27, 3911.

  1. Patent: Steven E. Rokita, Ken D. Karlin, Lei Li and N. N. Murthy “Dinuclear Copper Complexes Promote Selective Nucleobase Oxidation in a Sequence- and Conformation-Dependent Manner,” Patent April 20, 2004. International Publ. No. WO 03/052058.

     

  1. Markus Schatz, Michael Becker, Florian Thaler, Frank Hampel, Siegfried Schindler, Richard R. Jacobson, Zoltán Tyeklár, Murthy,N. N. Phalguni Ghosh, Qin Chen, JonZubieta, and Kenneth D. Karlin ; Copper(I) Complexes, Copper(I)/O2 Reactivity, and Copper(II) Complex Adducts, with a Series of Tetradentate Tripyridylalkylamine Tripodal Ligands, Inorganic Chemistry; 40(10); 2312 (2001).

  2. Rhames F. C., Murthy N. N., Karlin K.D. and Blackburn N. J. J Biol. Inorg. Chem. , 6, 567. (2001).

  3. Corsi, D.M.; Murthy, N. N. ; Young, V.G.; Karlin,K.D. “Synthesis, Structure, and Solution NMR Studies of Cyanide-Copper(II) and Cyanide-Bridged Iron(III)-Copper(II) Complexes” Inorg. Chem. 38, 848 (1999).

  4. Obias, H. V.; Lin, Y.; Murthy, N. N.; Pidcock, E.; Solomon, E.I.; Ralla, M.; Blackburn, N.J.; Neuhold, Y-M.; Zuberbuhler, A.D.; Karlin,K.D. “Peroxo-, Oxo-, and Hydroxo-Bridged Dicopper Complexes: Observation of Hexogenous Hydrocarbon Substrate Hydroxylation” J. Am. Chem. Soc. 120, 12960 (1998).

  5. Lee, D.-H.; Murthy, N. N.; Lin, Y.; nasir, S.; Karlin, K. D., Copper-Ion Complexes with Derivatized Chelating Pterin Ligands, Inorg. Chem., 36, 6328 (1997).

  6. Lee, D.-H.; Murthy, N. N.; Karlin, K. D., Binuclear Copper Complexes based on the 6,6′-bis[bis(2-pyridylmethyl amino]-2,2′-bipyridyl ligand, Inorg. Chem. 36, 5785 (1997).

  7. Frey, S.F.; Murthy, N.N. ; Weintraub, S. T.; Thompson S. T. and K.D. Karlin. Hydrolysis of Unactivated Esters and Acetonitrile Hydration by a Hydroxo-Diopper Complex, Inorg. Chem. 36, 956 (1997).

  8. Nanthakumar, A.; Fox, S., Murthy, N.N.; Karlin, K.D., Inferences from the 1H NMR Spectroscopic Study of an Antiferromagnetically Coupled Heterodinuclear Fe(III)-(X)-Cu(II) S = 2 Spin System (X = O2-, OH-), J. American Chemical Soc. 119, 3898 (1997).

  9. Murthy, N. N. ; Karlin,K.D.; Luchinat, C. and Bertini, I., 1H NMR and Electronic Relaxations in Paramagnetic Dinuclear Copper(II) Compounds, J. Am. Chem. Soc., 119, 2156 (1997).

  10. Inference from the 1H-NMR spectroscopic study of an antiferromagnetically coupled heterodinuclear Fe(III)-X-Cu(II) S=2 spin system (X=O2-, OH-). A. Nanthakumar, S. Fox, N. N.Murthy and K. D. Karlin, J. Am. Chem. Soc., 119, 3898-3906 (1997).

  11. NMR and electronic relaxations in pramagnetic dinuclear copper(II) compounds. N. N. Murthy, K.D. Karlin, C. Lichinat and I. Bertini, J. Am. Chem. Soc., 119, 2156-2162, (1997).

  12. Martens, C.F; Murthy, N. N., Obias, H.V. and Karlin, K.D. “Heme/non-heme iron-oxo complexes”, J. Chemical Soc. Chemical Commu.629 (1996).

  13. Lee, D.-H.; Murthy, N.N. and Karlin, K.D. “Copper(I)/Dioxygen Reactivity with Dinuclear Compounds: Catalytic Oxygenation and Oxo-transfer to a Ketone” Inorg. Chem. 35, 804 (1996).

  14. Frey, S.F.; Sun, H.H.J.; Murthy, N.N. and K.D. Karlin. “A New Trinuclear Copper Complex And Its Reaction With Plasmid DNA” Inorg. Chem. Acta 242, 329 (1996).

  15. Cox, C.; Ferraris, D., Murthy, N. N. and Lectka, T. “Copper(II)-Catalyzed Amide Isomerization: Evidence for N-Coordination”. J. American Chemical Soc.118, 5332 (1996).

  16. Karlin, K.D.; Fox, S.; Nanthakumar, A.; Murthy, N. N., Wei, N.; Obias, H.V.; Martens, C.F. “Copper-Dioxygen Chemistry and Modeling the Fe-Cu center in Cytochrome c Oxidase”, Pure and Applied Chemistry 67, No. 2, 289 (1995).

  17. Dong-Heon Lee; Wei, N.; Murthy, N. N.; Tyeklar, Z; Karlin, K. D.;Kaderli, S.;Jung, B. and Zuberbuhler, A.D. “Revrsible O2-Binding to a Dinuclear Copper(I) Complex with Linked TMPA {tris(2-pyridylmethyl)amine} Units: Kinetic-Thermodynamic Comparisions to Mononuclear Analogues” J. American Chemical Soc. 117, 12498 (1995).

  18. Reddy, B.J.; Murthy, N. N.; Karlin, K. D. and Balckburn, N.J. “Isocyanides as Ligand-Directed Indicators of Cu(I) Coordination in Copper Proteins. Probing the Inequivalence of the Cu(I) Centers in Reduced Dopamine-b-monooxygenase” J. American Chemical Soc. 117, 9826.(1995).

  19. Murthy, N. N. and Karlin, K.D.”Biomimetic Copper-Dioxygen Chemistry: Reversible O2-Binding and Mechanistic Insights into Cu(I)/O2 Mediated Arene Hydroxylation and Amide Hydrolysis”, Mechanistic Bioinorganic Chemistry, Advances in Chemistry Series, American Chemical Society; Eds. Thorp, H.H. and Pecoraro, V. L., Ch. 6, p165 (1995). (A book Chapter).

  20. Biomimetic copper-dioxygen chemistry: Reversible O2 binding and mechanistic insights into Ci(I)/Omediated arene hydroxylation and amide hydrolysis. N. N. Murthy and K. D. Karlin in “Mechanistic bioinorganic chemistry”, Advances in chemistry series, ACS., Eds. H. H. Thorp and V. L. Pecoraro, 246, 165-192, (1995).