• Research Publications
  • Patents
  1. Sulfamide-Lattice Restructuring to form dimensionally controlled molecular arrays and Gel-forming systems, Saripalli V. Raghava, Pushparathinam Gopinath, Bhartendu K. Srivastava, Venkatachalam Ramkumar, and Kannoth M. Muraleedharan, Chem. Eur. J., 2017, 23, 3658-3665.

    Link to full-size graphical abstract

  2. Towards a fragment-based approach in gelator design:halogen effects leading to thixotropic, mouldable and self-healing systems in aryl-triazolyl amino acid-based gelators, Bhartendu K. Srivastava and Kannoth M. Muraleedharan, Chem. Commun., 2017, 53, 4485-4488.

    Graphical abstract: Towards a fragment-based approach in gelator design: halogen effects leading to thixotropic, mouldable and self-healing systems in aryl-triazolyl amino acid-based gelators!

  3. Broad spectrum Anti-infective Properties of Benzisothiazolones and the Parallels in their Anti-bacterial and Anti-fungal effects, P. Gopinath, R. K. Yadav, P. K. Shukla, K. Srivastava, S. K. Puri and K. M. Muraleedharan Bioorganic & Medicinal Chemistry Letters, 2017, 27(5), 1291-1295.

  4. A Modular Approach Towards Drug Delivery Vehicles Using Oxanorbornane-based Non-ionic Amphiphiles, D. Sirisha Janni, U. Chandrasekhar Reddy, Soumya Saroj , K. M. Muraleedharan, J. Mater. Chem. B, 2016, 4, 8025-8032.

  5. FtsZ inhibition and Redox modulation with one chemical scaffold: Potential use of Dihydroquinolines against Mycobacteria, Sridevi Duggirala, John Victor Napoleon, Rakesh P. Nankar, Senu Adeeba V., Muraleedharan. K. Manheri,  Mukesh Doble, Eur. J. Med. Chem., 2016, 123, 557-567.

    Microsoft Word - Graphical abstract_26-02-06

  6. Aryl-triazolyl peptides for efficient phase selective gelation and easy removal of dyes from water, Bhartendu K Srivastava and Kannoth Manneri Muraleedharan, RSC Adv., 2016, 6, 29197-29201.

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  7. N-methylpyrrolidone Hydroperoxide/Cs2CO3 as an Excellent Reagent System for the Hydroxy-Directed Diastereoselective Epoxidation of Electron-Deficient Olefins, Napoleon John Victor, Gana Janardhanan and Kannoth Manheri Muraleedharan, Chem. Eur. J., 2015, 42, 14742-14747.

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  8. Conformational Switching in Heterochiral α,​β2,​3-​Hybrid Peptides in Response to Solvent Polarity, Dhayalan Balamurugan and Kannoth M. Muraleedharan, Eur. J. Org. Chem., 2015, 24, 5321-5325.

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  9. Can Helical Peptides Unwind One Turn at a Time? – Controlled Conformational Transitions in α,​β2,​3​Hybrid Peptides, Dhayalan Balamurugan and Kannoth M. Muraleedharan, Chem. Eur. J., 2015, 21(26), 9332-9338.

    http://onlinelibrary.wiley.com/store/10.1002/chem.201501198/asset/image_m/mcontent.gif?v=1&s=e5c17dad720098b4c0abbb77c2b28ac61ba8a0cc

  10. Peptide turns through just ‘one atom’! A sulfamide group nucleates folding and stabilizes new supramolecular topologies in short peptides, Pushparathinam Gopinath, Venkatachalam Ramkumar and Kannoth Manheri Muraleedharan, Cryst. Eng. Comm., 2014, 16, 10371-10375.

    http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C4CE01938E

  11. Tailoring strained oxanorbornane headgroups to dimensionally controlled nanostructures through hydrogen bonding, Nivarthi Ramesh, M. Ganesan, Nirod Kumar Sarangi, K. M. Muraleedharan and Archita Patnaik, RSC Adv., 2014, 4, 9762-9770.

    Graphical abstract: Tailoring strained oxanorbornane headgroups to dimensionally controlled nanostructures through hydrogen bonding

  12. An Expeditious and Metal-Free Synthetic Route towards Quinolones, Naphthyridones and Benzonaphthyridones, Napoleon John Victor and Kannoth Manheri Muraleedharan, Adv. Synth. Catal., 2014, 356(17), 3600–3614.

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  13. Hierarchical Preferences of Hydroxylated Oxanorbornane-Based Achiral Amphiphiles, D. Sirisha Janni and Muraleedharan K. Manheri, Langmuir., 2013, 29 (49), 15182–15190.

    Abstract Image

  14. Benzisothiazolones arrest the cell cycle at the G2/M phase and induce apoptosis in HeLa cells, Pushparathinam Gopinath, Krishnan Ramalingam, Kannoth Manheri Muraleedharan* and Devarajan Karunagaran, Med. Chem. Commun., 2013, 4, 749-752.

    http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C3MD00034F

  15. N-Substituted 1,2-Dihydroquinolines as Anticancer Agents: Electronic Control of Redox Stability, Assessment of Antiproliferative Effects, and Mechanistic Insights, Napoleon John Victor, Ramasamy Sakthivel, Kannoth Manheri Muraleedharan, and Devarajan Karunagaran, Chem. Med. Chem., 2013, 8(10), 1623–1628.

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  16. Chemical Environment as Control Element in the Evolution of Shapes – ‘Hexagons and Rods’ from an 11-Helical α,​β2,​3-hybrid Peptide, Dhayalan Balamurugan and Kannoth M. Muraleedharan, Soft Matter, 2012, 8, 11857-11862.

    Graphical abstract: Chemical environment as control element in the evolution of shapes – ‘hexagons and rods’ from an 11-helical α,β2,3-hybrid peptide

  17. Unprecedented Torsional Preferences in trans-α,​β2,​3-Amino acid Residues and Formation of 11-Helices in α,​β2,​3-Hybrid Peptides, Dhayalan Balamurugan and Kannoth M. Muraleedharan, Chem. Eur. J., 2012, 18, 9516-9520.

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  18. Oxanorbornane-based Amphiphilic Systems: Design, Synthesis and Material Properties, M. Ganesan and K. M. Muraleedharan, RSC Adv., 2012, 2(10), 4048-4051.

    Graphical abstract: Oxanorbornane-based amphiphilic systems: design, synthesis and material properties

  19. Direct Transformation of Baylis–Hillman Acetates into N-Substituted Quinolones Through an SN2’ → SNAr → (3,4–2,3 Shift) → Oxidation Sequence, John Victor Napoleon, Muraleedharan Kannoth Manheri, Synthesis., 2011, 20, 3379-3388.

  20. Highly Chemoselective Esterification Reactions and Boc/THP/TBDMS Discriminating Deprotections under Samarium(III) Catalysis, Gopinath Pushparathinam, Nilaya Surapaneni and Muraleedharan Kannoth Manheri, Org. Lett., 2011, 13 (8), 1932-1935.

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  21. Multi-chelation approach towards natural product-like skeletons: one-pot access to a nitrogen-containing tetracyclic framework from AlaAla dipeptide, Kasipandi Vellaisamy, John Victor Napoleon, Ramkumar Venkatachalam and Muraleedharan Kannoth Manheri, Chem. Commun., 2010, 46, 9212-9214.

    Graphical abstract: Multi-chelation approach towards natural product-like skeletons: one-pot access to a nitrogen-containing tetracyclic framework from AlaAla dipeptide

  22. Synthesis of β- Hydroxyphosphonate and 1,3-dihydroxy acyclic nucleoside analogs via 1,3-dipolar cycloaddition strategy, Ganesan M.,and Muraleedharan K. M., Nucleosides, Nucleotides and Nucleic acids., 2010, 29 (2) 91-96.

  23. Trans-​β2,​3-amino acid-based supramolecular synthons for probing the interrelationships between structure, torsion-directed assembly and isomorphism, Balamurugan Dhayalan, Ramkumar Venkatachalam and Muraleedharan Kannoth Manheri, Cryst. Growth Des., 2010, 10 (6), 2460–2464.

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  24. An efficient synthetic approach towards trans-​β2,​3-amino acids and demonstration of their utility in the design of therapeutically important β2,​3-peptides and ​α,​β2,​3-peptide aldehydes, Balamurugan Dhayalan and Muraleedharan Kannoth Manheri, Tetrahedron., 2009, 65, 10074-10082.

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  25. As many as six tandem reactions in one step! – Unprecedented formation of highly functionalized benzothiophenes, Gopinath Pushparathinam, Nilaya Surapaneni, Debiranjan Tripathy, Ramkumar Venkatachalam, and Muraleedharan Kannoth Manheri, Chem. Commun., 2009, 46, 7131-7133.

    Graphical abstract: As many as six tandem reactions in one step! Unprecedented formation of highly functionalized benzothiophenes

  26. A New Library of C-9 modified Artemisinin Analogs and Evaluation of their Anti-parasitic Activities. Menon, Rani B.; Kannoth, Muraleedharan M.; Tekwani, Babu L.; Gut, Jiri; Rosenthal, Phillip J. and Avery, Mitchell A., Combinatorial Chemistry & High Throughput Screening., 2006, 9 (10), 729-741.

  27. Microbial transformation of Artemisinin to 5-Hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger. Parshikov, I. A.; Miriyala, B.; Muraleedharan, K. M.; Avery, M. A. and Williamson, J. S., J. Ind. Microbiol. Biotechnol., 2006, 33 (5), 349-352.

  28. Biocatalysis of the anti-malarial artemisinin by Mucor ramannianus strains. Parshikov, I.A.; Miriyala, B.; Muraleedharan, K. M.; Illendula, A.; Avery, M. A. and Williamson, J. S., Pharmaceutical Biology., 2005, 43 (7), 579-582.

  29. Microbial transformation of Artemisinin to 7-hydroxyartemisinin. I. A. Parshikov; K. M. Muraleedharan; M. A. Avery and J. S. Williamson, Appl. Microbiol. Biotechnol., 2004, 64 (6), 782-786.

  30. Studies on the microbial transformations of 10-deoxoartemisinin by Fungi. I. A. Parshikov; K. M. Muraleedharan; M. A. Avery; J. S. Williamson, J. Nat. Prod., 2004, 67, 1595-1597.

  31. Structure-Activity Relationships of the Antimalarial Agent Artemisinin 8. Design, Synthesis and CoMFA Studies towards the Development of Artemisinin Based Drugs against Leishmaniasis and Malaria. Mitchell A. Avery; Kannoth M Muraleedharan; Prashant V. Desai; A. K. Bandhyopadhyaya; Babu L. Tekwani; and Marise Furtado, J. Med. Chem., 2003, 46, 4244-4258.

  32. Unique assemblies of alternating positively and negatively charged layers, directed by hydrogen bonds, ionic interactions and -stacking in the crystal structures of complexes between mellitic acid (benzene hexacarboxylic acid) and five planar aromatic bases. Karle Isabella; Gilardi, Richard D.; Ch.Chandrashekhar Rao; K. M. Muraleedharan; and Subramania Ranganathan, J. Chemical Crystallography., 2003, 33 (10), 727-749.

  33. The design and synthesis of redox core-alpha amino acid composites based on thiol-disulfide exchange mechanism and a comparative study of their zinc abstraction potential from [CCXX] boxes in proteins. Subramania Ranganathan; K. M. Muraleedharan; Parimal Bharadwaj; Dipankar Chatterji and Isabella Karle, Tetrahedron., 2002, 58, 2861-2874.

  34. Unusual cyclo–tetra and hexa peptidation of bis Boc cystine with cystine-diOMe: One step preparation of the novel 32-and 48-membered cyclo – tetra cystine and cyclo- hexa cystine. S. Ranganathan; K. M. Muraleedharan; M. Vairamani; A. C. Kunwar; A. Ravi Sankar, Chem. Commun., 2002, 314-315.

  35. One step transformation of Tricyclopentabenzene (Trindane, C15H18) to Bicyclo-(10.3.0)pentadec-1(12)ene-2,6,7,11-tetrone (C15H1804) and its Aldol Product,12-Hydroxy-16-oxatetracyclo(10.3.0.1,507,11)hexadec-7(11)ene-2,6-dione(C15H18O4). Subramania Ranganathan; K. M. Muraleedharan; Ch. Chandrashekhar Rao; M.Vairamani; and Isabella L. Karle, Org. Lett., 2001, 3 (16), 2447-2449.

  36. Stacking of a benzenehexacarboxylic acid core in the crystal structure of benzenehexacarboxylic acid – aminomethyl isobutyrate amide (MA-Aib6)-sodium nitrate complex. Ranganathan, Subramania; Muraleedharan, K. M.; Chandrashekhar Rao, C. H.; Vairamani, M.; Karle, Isabella L.; Gilardi, Richard D. Chem. Commun., 2001, 24, 2544-2545.

  37. The preference profile in ruthenium tetroxide oxidations. Ranganathan, S.; Muraleedharan, K. M.; Bhattacharya, D.; Kundu, D., J. Indian Chem. Soc., 1998, 10-12 (75), 583-589.

  38. One step transformation of tricyclopentabenzene (trindane) [C15H18] to 4-[1R,2S,4R,5S)-1,2,5-trihydroxy-3-oxabicyclo[3.3.0]octane-4 spiro-1′-(2′-oxocyclopentan)-2-yl]butanoic acid [C15H22O7]. Ranganathan, Subramania; Muraleedharan, K. M.; Bharadwaj, Parimal; Madhusudanan, K. P., Chem. Commun., 1998, 20, 2239-2240.

  1. A process for the preparation of the core structure in quinolone and naphthyridone class of antibiotics. Muraleedharan Kannoth Manheri and John Victor Napoleon, Indian patent application 1542/CHE/2012 on 18-04-2012.

  2. New Antiparasitic agents based on electrophilic sulfur in a heterocyclic frame-work: Mitchell A. Avery and Muraleedharan Kannoth M, (United States patent filed, UM file no. 2030 dated 03/28/05).

  3. Method for the preparation and derivatization of hydroxy metabolites of artemisinin and 10-deoxoartemisinin. Inventors: Mitchell A. Avery, I. A. Parshikov, Muraleedharan Kannoth M, Illendula Anuradha, John S. Williamson. (United States patent filed, UM file no. 001860 dated 08/06/04)

  4. Peroxide Compounds based on artemisinin as broad-spectrum anti-infective Agents. Inventors: Mitchell A. Avery, Muraleedharan Kannoth M (United States patent 2003, filed, PCT/US03/14571); WO 2003095444 A1

  5. Benziso-N (L-Histidine methylester)-thiazolone, process for the preparation thereof, and Use thereof, for RNA Polymerase Inhibition. Inventors: Subramania Ranganathan, Kannoth Manheri MuraleedharanUnited States patent # 6,350,879 B1.