DEPARTMENT OF CHEMISTRY
INDIAN INSTITUTE OF TECHNOLOGY MADRAS

Professor

DR. MURALEEDHARAN, K. M.

Biography

Muraleedharan K. M. hails from the Kannur Dt. of Kerala State. He did his Master’s degree in Chemistry studying at the School of Chemical Sciences, Mahatma Gandhi University during 1991 – 93. Subsequently he joined the research group of Professor Subramania Ranganathan at NIIST trivandrum for doctoral research which focused on the synthesis of models systems to understand molecular – assembly and dis – assembly, the key processes in every biological function. Following a brief stint at IICT Hyderabad (1999 – 2000), he moved to the research group of Professor Mitchell A. Avery at the Univesity of Mississippi, the USA for post – doctoral research where he was working on the development of broad – spectrum anti – infective agents. He joined the department of Chemistry at IIT Madras in 2006 as an Assistant Professor and since then, his group has been working on various projects under the broad umbrella of medicinal – and Bioorganic Chemistry.

Education

  • 2001 – 2006, Post - doctoral Research Associate, Department of Medicinal Chemistry, University. of Mississippi, USA (in the research group of Prof. Mitchell A. Avery).
  • 1999 - Ph. D from NIIST Trivandrum (Supervisor, Prof. Subramania Ranganathan)
  • 1993 - M. Sc from School of Chemical Sciences, Mahatma Gandhi University, Kerala.
  • 1991 - B. Sc from Nirmalagiri College, Calicut University, Kerala.

Research Interests

  • Development of short synthetic routes to bio - active compounds, and Lead optimizations to target diseases like cancer, Mycobacterium tuberculosis etc.
  • Studies to understand the mechanisms of drug action, uptake and localization, and also development of diagnostic sensors for biomedical applications.
  • Design, synthesis and development of new glycolipid mimics for drug delivery applications.
  • Design of new peptidic/nonpeptidic oligomers with specific conformational preferences in solution and their development into signal transduction modulators and antimicrobial agents.
  • Design of Supramolecular functional systems.

Representative Publications

 1‐Hydroxymethyl‐7‐oxabicyclo[2.2.1]hept‐2‐ene skeleton in enantiopure form through enzymatic  kinetic resolution, U. Chandrasekar, K. M. Muraleedharan, Chirality, 2019, 31, 336-347.

  Serine- and Threonine-derived Diamine Equivalents for Site-specific Incorporation of Platinum Centers in Peptides, and Anticancer Potential of these Conjugates, K. Sateeshkumar, V. Kasipandi, S. Soumya, V. Nalini, D. Karunagaran  and K. M. Muraleedharan, New J. Chem., 2018, 42, 2450-2458.

 Towards a fragment-based approach in gelator design: halogen effects leading to thixotropic, mouldable and self-healing systems in aryl-triazolyl amino acid-based gelators, B. K. Srivastava and K. M. Muraleedharan, Chem. Commun. 2017, 53, 4485-4488.

  FtsZ inhibition and Redox modulation with one chemical scaffold: Potential use of Dihydroquinolines against Mycobacteria, D. Sridevi, V. N. John, P. N. Rakesh, A. V. Senu, K. M. Muraleedharan,  Mukesh Doble, Eur. J. Med. Chem., 2016, 123, 557567.

Can Helical Peptides Unwind One Turn at a Time? – Controlled Conformational Transitions in α,β2,3-Hybrid Peptides, D. Balamurugan and K. M. Muraleedharan, Chem. Eur. J., 2015, 21, 9332-9338.

DR. MURALEEDHARAN, K. M.

Professor
mkm@iitm.ac.in
+91-44-2257-4233
  • CYB 301, Department of Chemistry
  • Indian Institute of Technology Madras
  • Chennai - 600036
  • INDIA

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