CY 3060 : Structure and Energetics of Biomolecules
Structure of proteins – primary, secondary, tertiary, quaternary – in relation to function; Enzyme kinetics – Inhibition; Aloosterism; Mechanism of enzyme action – cooperativity; Potential in drug design.
Free energy and chemical potential; Entropy and molecular viewpoint of the energetics – analysis of energetics in metabolic cycles; The concept of electrical double layers – example from membranes. Molecular spectroscopic techniques: Electronic absorption and emission spectroscopy; Rotational and vibrational spectroscopy; Raman spectroscopy, Circular Dichroism.
Text and References:
A.L. Lehninger, D.L. Nelson, M.M. Cox, Principles, Biochemistry, 1st Indian Edition, CBS Publishers, Delhi 1993.
L. Stryer, Biochemistry 4th Edition, W.H. Freeman & Company, New York 1995.
B. Alberts, D. Bray, J. Lewis, M. Rass, K. Roberts, J.D. Watson, Molecular Biology of the Cell, Garland Publishing Inc. New York, 1989.
K. Wilson, J. Walker (Eds), Practical Biochemistry : Principles and Techniques 4th Edition, Cambridge Low Priced Edition, 1996.